Cyclooxygenase-2 Inhibition for the Prevention of Subglottic Stenosis
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-2 inhibition for the prevention of subglottic stenosis.
OBJECTIVE To evaluate the role of targeted cyclooxygenase-2 inhibition in reducing scarring associated with a subglottic airway mucosal injury. DESIGN Thirty-four New Zealand white rabbits underwent anterior cricothyroidotomy. Subglottic stenosis (SGS) was created by carbon dioxide laser injury. INTERVENTION Treatment consisted of intraperitoneal injection of celecoxib or vehicle for 4 days...
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PURPOSE To determine if cyclooxygenase-2 (COX-2) is upregulated when lens epithelial cells (LEC) in clinical samples of cataracts and posterior capsule opacification (PCO) undergo epithelial-mesenchymal transition (EMT)-like changes. We also wanted to learn if inhibition of the enzymatic activity of COX-2 could prevent PCO formation. METHODS To ensure that EMT-like changes were occurring in L...
متن کاملSubglottic stenosis in pregnancy.
Subglottic stenosis (SGS) in pregnancy is rare but may cause a potentially life-threatening delivery and is a challenge to the anaesthetist and the obstetrician. Clinical signs of SGS may not be obvious and the diagnosis can be difficult. Patients usually present with shortness of breath rather than stridor. Many patients have been wrongly diagnosed with asthma and recurrent bronchitis before s...
متن کامل1 TITLE : Subglottic Stenosis
"This material was prepared by resident physicians in partial fulfillment of educational requirements established for the Postgraduate Training Program of the UTMB Department of Otolaryngology/Head and Neck Surgery and was not intended for clinical use in its present form. It was prepared for the purpose of stimulating group discussion in a conference setting. No warranties, either express or i...
متن کاملPost-intubation subglottic stenosis in children. Diagnosis, treatment and prevention of moderate and severe stenosis.
INTRODUCTION AND OBJECTIVES Subglottic stenosis is one of the most common causes of upper airway obstruction. Almost 90% of them result from endotracheal intubation. Therapy depends on the degree of stenosis, among other factors. Therapeutic approaches range from watchful waiting, in mild stenosis, to complex surgery for severe cases. We report our experience on the surgical management of post-...
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ژورنال
عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery
سال: 2012
ISSN: 0886-4470
DOI: 10.1001/archotol.2013.184